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Anti Estrogen Steroids Letrozole Powder Femara CAS 112809-51-5 For Breast Cancer
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Detailed Product Description
| Product Name: | Letrozole | Alias: | Femara |
|---|---|---|---|
| Usage: | Anti-cancer | Specification: | Orals |
| Storage Temp.: | 2-8°C | Whatsapp: | +8618186204104 |
| High Light: | human growth steroids,hgh human growth hormone |
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Anti Estrogen Steroids Letrozole Powder Femara CAS 112809-51-5 For Breast Cancer
Quick details
Letrozole CAS No. 112809-51-5
Melting point: 181-183°C
Boiling point: 563.5±60.0 °C(Predicted)
MF: C17H11N5
MF: C17H11N5
MW: 285.3
Density: 1.21±0.1 g/cm3(Predicted)
Solubility: DMSO: >50mg/mL
Appearance: White powder
Color: white to off-white
Uses: A nonsteroidal aromatase inhibitor structurally related to Fadrozole. Antineoplastic
Letrozole Descriptions
Letrozole (Femara) is an orally active nonsteroidal aromatase inhibitor. As a competitive inhibitor of the aromatase, Letrozole inhibits the conversion of androgens to estrogen (estrogen stimulates breast tissues and breast cancer reoccurrence) and gonadal steroidogenesis. It can be used for the treatment of breast cancer that is hormonally-responsive or has an unknown receptor status in postmenopausal women. Besides this, Letrozole also has some off-label use such as ovarian stimulation, pretreatment of termination of pregnancy, treatment of gynecomastia, treatment of endometriosis, and promoting spermatogenesis for male patients of nonobstructive azoospermia.
Letrozole uses
Letrozole is part of a new generation of highly selective aromatase inhibitors and is an artificially synthesized benzotriazole derivative. Letrozole inhibits aromatase to lower estrogen levels, thus preventing estrogen from stimulating tumor growth. Its in vivo activity is 150-250 times stronger than that of first generation aromatase inhibitor Amarante. As it is highly selective, it will not impact glucocorticoid, mineralocorticoid and thyroid functions; even at high dosages, it will not have any inhibiting effects on adrenal corticosteroid secretion, giving it a high treatment index. Letrozole has no latent toxicity towards any bodily systems and target organs, has no mutagenicity and carcinogenic effects, has minimal toxic side effects, is well-tolerated, and has stronger anticancer effects than other aromatase inhibitors and antiestrogen drugs. Letrozole is suitable for advanced breast cancer postmenopausal patients who have not responded to estrogen-suppressing treatment and for early breast cancer treatment. It is used to treat postmenopausal patients with advanced breast cancer and serves as a second-line treatment to follow unsuccessful antiestrogen treatment. Compared to the current standard Tamoxifen treatment, Letrozole can better prevent the risk of breast cancer recurrence.
Letrozole product show
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