99% White Powder Pharmaceutical Intermediates Hydrochloride CAS 129938-20-1

99% White Powder Pharmaceutical Intermediates Hydrochloride CAS 129938-20-1

Detailed Product Description

Quick Detail:

Product name: hydrochloride
Alias: hydrochloride; ; HCl
CAS No: 129938-20-1
MF: C21H23NO. HCl
MW: 341.88
Usage: pharmaceutical raw materials, the hormone
Assay: 99%
Brand: HKYC
Packaging Details: Foil bag or as requirement
Payment Terms: T/T, Western Union, MoneyGram
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Certificate of Analysis

Description:

Premature ejaculation (PE) is the most common male sexual dysfunction. hydrochloride, belonging to a class of drugs known as selective serotonin reuptake inhibitors or, was the first drug originally approved for the on-demand treatment of men with PE. We aimed to compare the intravaginal ejaculatory latency time (IELT), patient-reported global impression of change (PGIC), and adverse effect (AE) incidence associated with the use of (30mg and 60mg) versus placebo, and evaluate the differences in administering 60mg versus 30mg as on-demand medical oral therapy for the treatment of PE via a literature review and meta-analysis. Relevant randomized controlled trials (RCTs) were identified from PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (Cochrane Library) databases. Ultimately, a total of seven RCTs with 8039 patients were included. Our meta-analysis demonstrated that (in the 30mg and 60mg subgroup) resulted in significantly higher IELT, PGIC, and AE incidence relative to the placebo, with higher proportions observed for 60mg versus 30mg of administration. The most common AES were mild and tolerable. We conclude that (particularly the 60mg dosage) may be considered a safe and effective drug for patients with PE.

is the first compound developed specially for the treatment of premature ejaculation (PE) in men 18-64 years old. works by inhibiting the serotonin transporter, increasing serotonin's action at the post synaptic cleft, and as a consequence promoting ejaculatory delay. As a member of selective serotonin reuptake inhibitor (SSRI) family, was initially created as an antidepressant. However, unlike other SSRIs, is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant.

() as a new fast SSRI, a short half life, a selective 5 - HT reuptake inhibitor (SSRI), for the treatment of premature ejaculation and erectile dysfunction. is a selective 5 - HT reuptake inhibitor (SSRI), such drugs widely used to treat depression and related affective disorders

Application:

Randomized, double blind, placebo-controlled trials have confirmed the efficacy of for the treatment of PE. Different dosage has different impacts on different type of PE. 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of 30 mg in men with lifelong PE, but there is no difference in men with acquired PE. , given 1-3 hours before sexual episode, prolongs IELT, increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE.

Since PE is associated with personal distress, interrelationship difficulty, provides help for men with PE to overcome this condition. Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE. Waldinger's meta analysis shows that the use of these conventional antidepressants increasing IELT from two to ninefold above base line in comparison of three to eightfold when is used.

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