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Toremifene Citrate Anti Estrogen Steroids Hormonal Antitumor APIs For Cancer Treatment
Product Details:
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Detailed Product Description
| CAS: | 89778-27-8 | State: | Powder |
|---|---|---|---|
| Molecular Formula: | C26h28clno.C6h8o7 | Molecular Weight: | 598.09 |
| Boiling Point: | 535.1 º C At 760 MmHg | Melting Point: | 158-164 º C |
| Degree: | <0.4% | Heavy Metals: | <10PPm |
| Assay(by HPLC): | 99.64% | ||
| High Light: | Estrogen Blocker Steroids,Anti Estrogen Supplements |
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Toremifene Citrate Anti Estrogen Steroids Hormonal Antitumor APIs For Cancer Treatment
Quick Detail:
An estrogen agonist/antagonist that blocks the growth-stimulating effects of estrogen in the tumor.
Description:
Toremifene citrate
Product Name: Toremifene citrate
CAS No.: 89778-27-8
M.F.: C32H36ClNO8
M.W.: 598.08
Packing: 1kg/foil bag
Assay: 99%
Melting Point: 158-164℃
Appearance: White powder
Specifications:
Description |
White or Almost White Crystalline Powder | white powder |
| Identification | A.B. | Positive |
| Assay | 97.0~103.0% | 99.0% |
| Specific Rotation | +101°~+105° | +102.6° |
| Loss On Drying | 1.0%max | 0.28% |
| Organic Volatile Impurities | meets the requirement. | Conforms |
| Related Substances | meets the requirement. | Conforms |
| Residual Solvents | meets the requirement. | Conforms |
| Particle Size | 100% ≤ 20 microns |
Conforms |
Applications:
Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene citrate is FDA-approved for use in advanced (metastatic)breast cancer. It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.
Used for Metastatic breast cancer in postmenopausal women.
PO 60 mg once daily with or without food. Treatment is generally continued until disease progression is observed.
Function:
Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene citrate is FDA-approved for use in advanced (metastatic) breast cancer. It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.
It has already been covered that Toremifene is a SERM, and serves to block Estrogen at various receptor sites in certain tissues within the body (breast tissue in particular). As a layman explanation, Toremifene pretends to be a 'fake' Estrogen that occupies Estrogen receptors within breast tissue. With these receptors occupied by Toremifene, real Estrogen cannot perform their jobs there. Toremifene does not reduce total blood plasma levels of Estrogen. In addition to being antagonistic to Estrogen receptors in breast tissue, it is also antagonistic to Estrogen at the hypothalamus gland (this essentially 'tricks' the hypothalamus into thinking there is little or no circulating Estrogen levels in the body, causing it to increase its manufacture of Testosterone so that it can utilize aromatization to restore these levels.
Toremifene is also agonistic to Estrogen receptors in other tissues in the body (within the liver in particular). This means that whileToremifene will act as an anti-estrogen in breast tissue and the hypothalamus, it will act as an Estrogen within the liver. This can have beneficial impacts especially during an anabolic steroid cycle, such as improving and shifting cholesterol levels into a more favorable range.
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