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13647-35-3 COA Raw Steroid Powders Trilostane For Breast Cancer / Canine Cushing′s Disease Treatment
Product Details:
Payment & Shipping Terms:
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Detailed Product Description
| Product Name: | Trilostane | CAS No: | 13647-35-3 |
|---|---|---|---|
| Appearance: | White Powder | Assay: | 99% |
| Usage: | For Breast Cancer Treatment | Molecular Formula: | C42h68n2o2 |
| Molecular Weight: | 633.0015 | Einecs: | 237-133-0 |
| High Light: | Raw Hormone Powders,Steroid Raws |
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13647-35-3 COA Raw Steroid Powders Trilostane For Breast Cancer / Canine Cushing′s Disease Treatment
Quick Detail:
Trilostane
Synonym: Vetoryl
CAS Registry Number: 13647-35-3
Alias: 99%
Einecs No: 237-133-0
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation
Appearance: White crystalline powder
Manufacturer: Yuan Cheng
Molecular Weight: 329.4333
Molecular Formula: C20H27NO3
Melting point: 264° C
Boiling point: 497.8° C at 760 mmHg
Refractive index: 1.61
Flash point: 254.8° C
Vapour Pressur: 5.39E-12mmHg at 25° C
Lead time: 1-2 days upon receipt of payment
Delivery Term: Products below 200Kg by air; Over 200Kg by ship
Delivery Time: Average 6 days by air; 15 days by ship
Usage: Trilostane can inhibit cortical hormone in the process of synthesis of 3 beta dehydrogenase,
make the cortisol, aldosterone synthesis decreased, clinically used in the treatment of Cushing syndrome
(hypercortisolism) and primary aldosteronism. This product also had significantly effect to decreased serum testosterone level.
Description:
Trilostane is an inhibitor of isoforms 3β-HSD and 3β-HSD2 of the enzyme 3β-hydroxysteroid dehydrogenase,
which plays a role in adrenal steroid biosynthesis. Investigators believe
that Arg195 in 3β-HSD versus Pro195 in 3β-HSD2 attributes to the competitive inhibition of
3β-HSD, but not
3βHSD2 by Trilostane. Research shows that trilostane is effective in suppressing the intracellular
production oin LNCaPFGC prostate cancer cells and inhibiting cortisol biosynthesis in the human
adrenal gland. This product serves as a useful tool in steroid biosynthesis research.
Application:
Trilostane can suppress cortical hormone synthesis process of 3 beta dehydrogenase, make cortisol,
aldosterone synthesis reduce, clinical used in the treatment of Cushing syndrome(cortisol increase
disease) and primary aldosteronism,the effect is not good than testosterone metyrapone. This product
has significantly reduced blood testosterone level role, may relevant to its inhibit synthetic.
Specifications(COA and HPLC):
Test Items |
Specification |
Test Results |
|
Appearance |
white oralmost white,crystalline powder |
Conform |
|
Solubility |
Freely soluble in water,practically insoluble or very slightly soluble in alcohol and in methylene chloride. |
Conform |
|
Identification |
A |
The UV absorption spectrum of the sample shows an absorption maximum at 276nm.The specific absorbance at the Maximum is55 to 64. |
Conform |
B |
Infraed absorption spectrophotometry. |
Conform |
|
C |
Chromatogram obtained with test solution (b) is similar in position color & size to the principal spot in the chromatogram obtained with the reference solution. |
Conform |
|
D |
An orange-red color develop in methylene chloride layer. |
Conform |
|
E |
It geves reaction (a) of sulphates. |
Conform |
|
Appearance of solution |
Solution S is clear and not more intensely coloured than reference solution in BY6. |
Conform |
|
Optical rotation |
negative 0.10° to +0.10°determined on solution S. |
+0.01° |
|
Acidity or alkalinity |
NMT 0.4ml of 0.01M HCL is required to change the color of the indicator to red. |
Conform |
|
Related substances |
Impurity J ≤0.20% |
Conform |
|
Any other impurity ≤0.30% |
Conform |
||
Total impurity ≤1.0% |
Conform |
||
Boron |
≤50ppm |
Conform |
|
Sulphated ash |
≤0.10% |
0.06% |
|
Loss on drying |
≤0.5% |
0.30% |
|
Assay(on dried basis) |
98.0~101.0% |
99.5% |
|
Conclusion |
The test results above BP2009 |
||
Trilostane Specifications:
| Test Items | Specification | Test Results | |
| Appearance | white oralmost white,crystalline powder | Conform | |
| Solubility | Freely soluble in water,practically insoluble or very slightly soluble in alcohol and in methylene chloride. |
Conform | |
| Identification | A | The UV absorption spectrum of the sample shows an absorption maximum at 276nm.The specific absorbance at the Maximum is55 to 64. |
Conform |
| B | Infraed absorption spectrophotometry. | Conform | |
| C | Chromatogram obtained with test solution (b) is similar in position color & size to the principal spot in the chromatogram obtained with the reference solution. |
Conform | |
| D | An orange-red color develop in methylene chloride layer. | Conform | |
| E | It geves reaction (a) of sulphates. | Conform | |
| Appearance of solution | Solution S is clear and not more intensely coloured than reference solution in BY6. |
Conform | |
| Optical rotation | negative 0.10° to +0.10°determined on solution S. | +0.01° | |
| Acidity or alkalinity | NMT 0.4ml of 0.01M HCL is required to change the color of the indicator to red. |
Conform | |
| Related substances | Impurity J ≤0.20% | Conform | |
| Any other impurity ≤0.30% | Conform | ||
| Total impurity ≤1.0% | Conform | ||
| Boron | ≤50ppm | Conform | |
| Sulphated ash | ≤0.10% | 0.06% | |
| Loss on drying | ≤0.5% | 0.30% | |
| Assay(on dried basis) | 98.0~101.0% | 99.5% | |
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