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|Product Name:||Tamoxifen Citrate||CAS:||72-63-9|
Nolvadex Tamoxifen Raw Steroid Powders,
Citrate Raw Steroid Powders,
54965 24 1 Bodybuilding Supplement Powder
Product name: Tamoxifen Citrate
CAS No: 54965-24-1
Molecular Formula: C26H29NO.C6H8O7
Molecular weight: 563.64
MP: 140-144 ºC
Appearance: white crystalline powder
Drug Class: Anabolic Androgenic Steroid
Other drugs in same class:Anastrozole,Letrozole,Tamoxifen citrate,Exemestane
Tamoxifen Citrate is the citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma and other cancers that overexpress PKC.
Tamoxifen is currently used for the treatment of both early and advanced estrogen receptor-positive (ER-positive or ER+) breast cancer in pre- and post-menopausal women. Additionally, it is the most common hormone treatment for male breast cancer. It is also approved by the FDA for the prevention of breast cancer in women at high risk of developing the disease.It has been further approved for the reduction of contralateral (in the opposite breast) cancer. The use of tamoxifen is recommended for 10 years.
In 2006, the large STAR clinical study concluded that raloxifene is equally effective in reducing the incidence of breast cancer, but after an average 4-year follow-up, although the difference was not statistically significant, there were 36% fewer uterine cancers and 29% fewer blood clots in women taking raloxifene than in women taking tamoxifen.
1. Nolvadex is not an anabolic steroid but is used to manage side effects from steroids.
2. Nolvadex is a mixed estrogen agonist/antagonist of the same type as Clomid.
3. Tamoxifen Citrate is the raw material of Nolvadex.
4. Nolvadex is also a kind of medicine to treat cancer.
5. Nolvadex (tamoxifen citrate) is very comparable to Clomid.
6. Nolvadex behaves in the same manner in all tissues with Clomid.
For the treatment of advanced, recurrent breast cancer and ovarian cancer and other illnesses. Used as an antineoplastic raw materials.
Biological Activity: Estrogen receptor antagonist/partial agonist. Selective and potent inhibitor of mammalian sterol isomerase. Neuroprotective in female rats in vivo . Also high affinity agonist at the membrane estrogen receptor GPR30.
Nolvadex and Clomid are two of the most popular Selective Estrogen Receptor Modulators (SERMs) in the world and part of the supplemental plan for many performance enhancing athletes. More athletes buy Nolvadex for PCT purposes than any other purpose; in-fact, more performance enhancers buy Nolvadex for their PCT use than any other medication available.
In-fact, more performance enhancers buy Nolvadex for their PCT use than any other medication available. As you understand the purpose of the PCT period is to stimulate natural testosterone production after a cycle of anabolic steroids has been discontinued; this is necessary as anabolic steroids suppress natural testosterone production. Further, beyond testosterone stimulation this is the period when we begin normalizing our body but in the case of Tamoxifen Citrate it is testosterone production we are concerned with here.
Gynecomastia(male breast enlargement) is one of the most worrisome side-effects that can occur due to anabolic androgenic steroid use, fortunately you can buy Nolvadex and combat this effect; no, Tamoxifen Citrate will not reduce the amount of estrogen in your body but it will prevent a large portion of it from binding and this provides protection.
Nolvadex is the trade name for the drug tamoxifen citrate, it is a non-steroidal agent that demonstrates potent anti-estrogenic properties. The drug is technically an estrogen agonist/antagonist, which competitively binds to estrogen receptors in various target tissues. With the tamoxifen molecule bound to this receptor, estrogen is blocked from exerting any action, and an anti-estrogenic effect is achieved. Since many forms of breast cancer are responsive to estrogen, the ability of tamoxifen citrate to block its action in such cells has proven to be a very effective treatment. It is also utilized successfully as a preventative measure, taken by people with an extremely high familial tendency for breast cancer. While Nolvadex is effective against estrogen, it is not our strongest available remedy.Since Nolvadex is milder in comparison, it is more widely applicable and usually the first treatment option.
|Product name||Tamoxifen citrate (Nolvadex)|
|Appearance||White crystalline powder|
|Identification||IR , UV conform||Conform|
|Loss on drying||≤0.5ml||0.21ml|
|Residue on ignition||Not more than 0.2%||0.07ml|
|Iron||Not more than 0.005%||0.0017%|
|Heavy metals||Not more than 0.001%||0.0006%|
|Related substances||Total: Not more than 1.0%
Individual: Not more than 0.5%
|E-isomer||Not more than 0.3%||0.18%|
|Organic volatile impurities||Conforms||Conforms|
Tamoxifen is used to treat infertility in women with anovulatory disorders. It is given at days 3 to 7 of a womans cycle.
Tamoxifen improves fertility in males with infertility by disinhibiting the hypothalamic–pituitary–gonadal axis (HPG axis) via ER antagonism and thereby increasing the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and increasing testicular testosterone production.
Occasionally tamoxifen is used in treatment of the rare conditions of retroperitoneal fibrosisand idiopathic sclerosing mesenteritis.
Nolvaxyl Side Effects
Sudden numbness or weakness, sudden severe headache, confusion, problems with vision, speech, or balance, chest pain, loss of appetite, increased thirst, muscle weakness, confusion, and feeling tired or restless, unusual vaginal bleeding or discharge or irregular menstrual periodsm, as well asrapid breathing, fast heart rate, pain, swelling, warmth, nausea, swelling in your hands or feet, vaginal itching or dryness, headache, dizziness and depression.
Nolvaxyl Contraindications/Precautionary Measures
Not recommended in case of hypersensitivity to the drug, leukopenia, thrombocytopenia, hyperlipidemia, hypercalcemia, cataracts, pregnancy and thrombophlebitis. During treatment it is necessary to monitor the leukocytes, platelets, calcium levels and blood coagulation system indices. In some pre-menopausal women, administering the drug to treat breast cancer may suppress the menstruation process.
How should I take tamoxifen?
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
Tamoxifen can be taken with or without food.
While using tamoxifen, you may need frequent blood tests.