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|Product Name:||Gbl||Advantages:||Reship Policy|
Pharma Raw Materials,
|Synonyms:||FEMA 3291;GAMMA-BUTYROLACTONE;GAMA-BUTYROLACTONE;GAMMA-HYDROXYBUTYRIC ACID LACTONE;GBL;GBL-EL;G-BUTYROLACTONE;endo-cis-5-norbornene-endo-2,3-dicarboxylic anhydride|
|Product Categories:||organic interme-;Pharmaceutical Intermediates;-;Heterocycles;Miscellaneous Reagents;Halogenated Heterocycles ,Thiophenes ,Thiazolines/Thiazolidines|
γ-Butyrolactone (GBL) is a hygroscopic colorless liquid with a weak characteristic odor. Soluble in water, GBL is a common solvent and reagent in chemistry as well as being used as a flavouring, as a cleaning solvent, as a superglue remover, and as a solvent in some wet aluminium electrolytic capacitors. In humans it acts as a prodrug for γ-hydroxybutyric acid (GHB), and it is used as a recreational intoxicant with effects similar to alcohol.
A milliliter of pure GBL metabolizes to the equivalent 1.65g of NaGHB, the common form, so doses are measured in the single milliliter range, either taken all at once or sipped over the course of a night.
GBL is a lactone. It is hydrolyzed under basic conditions, for example in a sodium hydroxide solution into sodium gamma-hydroxybutyrate, the sodium salt of gamma-hydroxybutyric acid. Under acidic conditions it forms an equilibrium mixture of both compounds. These compounds then may go on to form a polymer. When treated with a non-nucleophilic base, like lithium diisopropylamide, GBL can become an alpha-carbon nucleophile. The related compound caprolactone can be used to make a polyester in this manner.
GBL is rapidly converted into GHB by paraoxonase (lactonase) enzymes, found in the blood. Animals which lack these enzymes exhibit no effect from GBL. GBL is more lipophilic (fat soluble) than GHB, and so is absorbed faster and has higher bioavailability. Because of these pharmacokinetic differences, GBL tends to be more potent and faster-acting than GHB, but has a shorter duration; whereas the related compound 1,4-butanediol (1,4-B) tends to be slightly less potent, slower to take effect but longer-acting than GHB.
It is an important organic synthesis intermediate which can be used to synthesize indole butyric acid, butyric acid, succinic acid, α-pyrrolidone, N-methylpyrrolidone, vinyl pyrrolidone, acetyl-γ-butyrolactone, cyclopropylamine, ciprofloxacin, vitamin B1, chlorophyll and so on;
It is a non-toxic high boiling point solvent with high solubility and safe and convenient usage and management;
It is used as an extractant for butadiene, aromatic, advanced grease petroleum processing;
It is used as an acrylonitrile fiber spinning solvent in the chemical fiber industry.
It is a thinner and curing agent commonly used in wool, nylon, acrylonitrile and other fiber dyeing auxiliaries and other chemical industries.
|Appearance||Transparent liquid||Transparent liquid|
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