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|Product Name:||Procaine||Advantages:||Reship Policy|
|Type:||Pharmaceutical Intermediate||Appearance:||White Powder|
Pharma Raw Materials,
|Synonyms:||2-(Diethylamino)ethyl 4-aminobenzoate;2-(Diethylamino)ethyl p-aminobenzoate;2-(diethylamino)ethylp-aminobenzoate;2-diethylaminoethyl4-aminobenzoate;2-Diethylaminoethylester kyseliny p-aminobenzoove;2-diethylaminoethylesterkyselinyp-aminobenzoove;2-diethylaminoethylp-aminobenzoate;4-Aminobenzoic acid diethylaminoethyl ester|
Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine. It acts mainly by being a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.
Procaine was first synthesized in 1905,shortly after amylocaine. It was created by the German chemist Alfred Einhorn who gave the chemical the trade name Novocaine, from the Latin nov- (meaning new) and -caine, a common ending for alkaloids used as anesthetics. It was introduced into medical use by surgeon Heinrich Braun. Prior to the discovery of amylocaine and procaine, cocaine was the most commonly used local anesthetic. Einhorn wished his new discovery to be used for amputations, but surgeons preferred general anesthetic. Dentists, however, found it very useful. Einhorn was displeased by this[why?] and spent many years touring dental schools to advise them not to use it.
Procaine is used less frequently today since more effective (and hypoallergenic) alternatives such as lidocaine (Xylocaine) exist. Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, and is often coadministered with epinephrine for the purpose of vasoconstriction. Vasoconstriction helps to reduce bleeding, increases the duration and quality of anesthesia, prevents the drug from reaching systemic circulation in large amounts, and overall reduces the amount of anesthetic required.Unlike cocaine, a vasoconstrictor, procaine does not have the euphoric and addictive qualities that put it at risk for abuse. MDMA manufacturers also use procaine as an additive at ratios ranging from 1:1 up to 10% MDMA with 90% procaine, which can be life-threatening.
Procaine, an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis intopara-amino benzoic acid (PABA), which is then excreted by the kidneys into the urine.
Procaine is the primary ingredient in the controversial preparation Gerovital H3 by Ana Aslan (Romania), which is claimed by its advocates to remedy many effects of aging. The mainstream medical view is that these claims were seriously studied and discredited in the 1960s.
A 1% procaine injection has been recommended for the treatment of extravasation complications associated with venipuncture (along with moist heat, ASA, steroids, antibiotics). It has likewise been recommended for treatment of inadvertent intra-arterial injections (10 ml of 1% procaine), as it helps relieve pain and vascular spasm.
|Appearance||White crystalline powder|
|Assay (C13H20N2O2·HCl)||99.0% to 101.0%||99.5%|
|Solution Appearance||Clear and colorless||Confirm|
|Related impurities||impurity A:≤0.01%||0.002%|
|Single unspecified impurity: ≤0.1%||0.03%|
|Total impurity: ≤0.5%||0.19%|
Local Anesthetic Drugs we supply
|Procaine Base||CAS 59-46-1a|
|Lidocaine HCl||CAS 73-78-9|
|Lidocaine Hydrochloride||CAS 51-05-8|
|Xylocaine Lidocaine||CAS 137-58-6|
|Tetracaine HCl||CAS 136-47-0|
|Propitocaine Hydrochloride||CAS 1786-81-8|
|Aarticaine Hydrochloride||CAS 23964-57-0|
|Procaine Hydrochloride||CAS 51-05-8|
|Tetracaine hydrochloride||CAS 136-47-0|
|Lidocaine Base||CAS 137-58-6|
|Dyclonine hydrochloride||CAS 536-43-6|
|Tetracaine Base||CAS 94-24-6|
|Dibucaine Hydrochloride||CAS 61-12-1|
|Proparacaine Hydrochloride||CAS 5875-06-9|
|Ropivacaine Hydrochloride||CAS 98717-15-8|
|Bupivacaine Hydrochloride||CAS 14252-80-3|
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