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99% Purity Effective Pharmaceutical Material Cabergoline for Treatment -Parkinson 81409-90-7

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99% Purity Effective Pharmaceutical Material Cabergoline for Treatment -Parkinson 81409-90-7

China 99% Purity Effective Pharmaceutical Material Cabergoline for Treatment -Parkinson 81409-90-7 supplier
99% Purity Effective Pharmaceutical Material Cabergoline for Treatment -Parkinson 81409-90-7 supplier 99% Purity Effective Pharmaceutical Material Cabergoline for Treatment -Parkinson 81409-90-7 supplier 99% Purity Effective Pharmaceutical Material Cabergoline for Treatment -Parkinson 81409-90-7 supplier

Large Image :  99% Purity Effective Pharmaceutical Material Cabergoline for Treatment -Parkinson 81409-90-7

Product Details:

Place of Origin: China
Brand Name: YIHAN
Certification: GMP,USP,BP,ISO 9001
Model Number: Cabergoline

Payment & Shipping Terms:

Minimum Order Quantity: 10G
Price: USD0.1-2 +g
Packaging Details: Discreet Package or as Required.
Delivery Time: 3-5 work days
Payment Terms: MoneyGram,Paypal, T/T, Western Union
Supply Ability: 5000kg/Month
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Detailed Product Description
Product Name: Cabergoline Advantages: Reship Policy
Suitable For: Adult CAS: 81409-90-7
Type: Pharmaceutical Intermediate Appearance: White Crystalline Solid
High Light:

Pharma Raw Materials


Medicine Intermediate

1. Basic Info

Product Name: Cabergoline
Synonyms: cabergoline powder E:candyli(at)speedgainpharma(dot)com;(8β)-N-[3-(Dimethylamino)propyl]-N-[(ethylamino)earbonyl]-6-(2-propenyl)ergoline-8-carboxamide;(8R)-6-(2-Propenyl)-8-[[(ethylaminocarbonyl)[3-(dimethylamino)propyl]amino]carbonyl]ergoline;CG-101;N-(Ethylcarbamoyl)-N-[3-(dimethylamino)propyl]-6-allylergoline-8β-carboxamide;N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)ergoline-8β-carboxamide;Cabergoline (125 mg);1-[(6-Allylergoline-8β-yl)carbonyl]-1-[3-(dimethylamino)-propyl]-3-ethylurea
CAS: 81409-90-7
MF: C26H37N5O2
MW: 451.6
EINECS: 200-419-0
Product Categories: Neurochemicals;Pharmaceuticals;API;Intermediates & Fine Chemicals
Mol File: 81409-90-7.mol
Cabergoline Structure



2. Descriptions:


Cabergoline, (6aR,9R,10aR)-7-allyl-N-(3-(dimethylamino)propyl)-N-(ethylcarbamoyl)-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide (Dostinex), is a white powder soluble inalcohol, chloroform, and N,N-dimethylformamide; slightlysoluble in acidic solutions and in n-hexane; and insoluble inwater. Following oral administration, peak plasma concentrationsare reached within 2 to 3 hours. Cabergoline ismoderately bound to plasma proteins in a concentrationindependentmanner. The absolute bioavailability of cabergolineis unknown. Cabergoline is extensively metabolizedby the liver, predominantly via hydrolysis of the acylureabond of the urea moiety. CYP450 metabolism appears to beminimal. The major metabolites identified thus far do not contribute to the therapeutic effect of cabergoline. Lessthan 4% is excreted unchanged in the urine. Fecal excretionrepresents the main route of cabergoline elimination. Thereare no reports of interactions of cabergoline with other antiparkinsonianagents. Clarithromycin may elevate theplasma concentration of cabergoline by the inhibition ofboth CYP3A4 and P-glycoprotein.Cabergoline is a potentD2 receptor agonist and is indicated for the treatment ofhyperprolactinemic disorders, either idiopathic or causedby pituitary adenomas.


Selective D 2 -like dopamine receptor agonist (K i values are 0.7, 1.5, 9.0 and 165 nM for D 2 , D 3 , D 4 and D 5 receptors respectively) that also displays high affinity for several serotonin receptor subtypes (K i = 1.2-20.0 nM for 5-HT 1A , 5-HT 1D , 5-HT 2A and 5-HT 2B ). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.


3. detail


Cabergoline is a potent, selective, and long-lasting dopamine D2receptor agonist launched in 1993 in Belgium as a prolactin inhibitor. A single 1 mg dose of cabergoline effectively prevents puerperal lactation for up to 14 days, remarkably superior to other drugs that require a daily regimen. It has a low rate of rebound breast activity and good tolerability. Cabergoline is also in clinical trials for Parkinson's disease, breast cancer, and hyperprolactinaemia.


ChEBI: An N-acylurea that is (8R)-ergoline-8-carboxamide in which the hydrogen attached to the piperidine nitrogen (position 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substit ted by a 3-(dimethylamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson's disease and of disorders associated with hyperprolactinaemia.


4. Applications:


There are several ways we can use caber in bodybuilding. Since it is a dopamine agonist, some athletes believe they can take it to give themselves an adrenaline rush during a sporting event. Also, the addition of dopamine can improve motor skills and give you an edge over your competition. In theory, you will be able to workout much harder and be able to ignore pain pushing your muscles to the limit.


The main way bodybuilders use cabergoline is when they run a compound which increases prolactin levels in the body. Trenbolone will turn into prolactin, and, when abused, you can get prolactin based gynecomastia. In addition, a spike in prolactin can cripple your sex drive. Even when you do not run a compound that increases prolactin, caber can still help normalize your libido when you are playing with your hormones.


Another way caber can be used in bodybuilding is by its mechanism of mimicking dopamine being produced from food intake. Ever had a craving for New York style greasy pizza, oreo ice cream or some other treat you know you shouldn't have? Well, when you take cabergoline, the dopamine being released can act as the pleasure chemical, which can make a bite of that pizza satisfy you rather than eating the whole pie. This aids weight loss goals and helps you stay lean.


And finally, sleep! Many bodybuilders who take cabergoline report improved sleep thanks to the dopamine mimic. This allows you to sleep more, deeper and longer.


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About us:

we, Yihan Industrial Co., Ltd from china are specilized in steroids powder , semi-finished liquids , peptides , Sarm powder,HGH,HCG,Finished Liquid and other pharmaceutical materials for many years .

If you have any further questions or need a sample,Please do not hesitate to contact me.Thank you!

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