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Safe Health EE2 Estrogen Steroid Medical Raw Hormone Powders Einecs 200-350-6

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Safe Health EE2 Estrogen Steroid Medical Raw Hormone Powders Einecs 200-350-6

China Safe Health EE2 Estrogen Steroid Medical Raw Hormone Powders Einecs 200-350-6 supplier
Safe Health EE2 Estrogen Steroid Medical Raw Hormone Powders Einecs 200-350-6 supplier Safe Health EE2 Estrogen Steroid Medical Raw Hormone Powders Einecs 200-350-6 supplier

Large Image :  Safe Health EE2 Estrogen Steroid Medical Raw Hormone Powders Einecs 200-350-6

Product Details:

Place of Origin: China
Brand Name: YIHAN
Certification: GMP,SGS,ISO,KOSHER,
Model Number: 57-63-6

Payment & Shipping Terms:

Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: discreet packing
Delivery Time: within 5 days
Payment Terms: Western Union, MoneyGram, T/T
Supply Ability: 300kg per week
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Detailed Product Description
Color: White Powder Category: Pharmaceutical Intermediates
CAS: 57-63-6 Einecs: 200-350-6
Residual Solvents: 235ppm;No Detectable; No Detectable Assay: 99.5%
Conclusion: Qualified Solubility: Conforms

Safe Health EE2 Estrogen Steroid Medical Raw Hormone Powders Einecs 200-350-6

 

 Product Name:

Ethynyl estradiol

Alias:

 Ethynyl estradiol

 CAS NO.:

 57-63-6

Purity:

99%

 Appearance:

white powder

Application:

Medicine intermediate

 

Estrogen Steroids Novestrol Ethynyl Estradiol
Product Name Ethynyl Estradiol Powder
CAS Registry Number 57-63-6
EINECS 200-342-2
Molecular formula C20H24O2
Molecular weight 296.41
Purity 99%
Grade Pharmaceutical Grade
Appearance white crystalline powder

Ethinyl estradiol (EE2) also sometimes written as 17α-ethinyl estradiol, ethinylestradiol, ethynyl estradiol, or ethinyl œstradiol, is a derivative of 17β-estradiol (E2), the major endogenous estrogen in humans. EE2 is an orally bioactive estrogen used in many formulations of combined oral contraceptive pills. It is one of the most commonly used medications for this purpose.

Transdermal ethinyl estradiol carries a greater risk of clot formation and venous thromboembolism than naturally occurring 17β-estradiol, which some have theorized to be related to different amounts of hepatic metabolism after absorption. The same contraindications and precautions apply for EE2 as with other estrogen medications.

Estinyl was a preparation of EE2 alone that was used for the management of menopausal symptoms and female hypogonadism.

EE2 is released into the environment as a xenoestrogen from the urine and feces of people who take it as a medication.

The major concern with unopposed estrogen (without progestogen) is of endometrial cancer. As such, the medication is generally prescribed with progesterone in the setting of birth control.

While E2 is readily absorbed when taken orally, it is also quickly inactivated by the liver. Substitution at C17 of the estrane steroid with an ethinyl group served to provide an estrogen that is much more resistant to degradation and paved the way for the development of oral contraceptives.

EE2 is absorbed in the small intestine and reaches a serum peak about 2 hours later. It undergoes extensive metabolism in the liver involving the cytochrome P450 3A4 isoenzyme. EE2 and its metabolites are excreted with the bile. Due to the effect of enterohepatic circulation a second peak is seen several hours later. Individually, wide variations exist in the overall absorption process, and can be further modified by drugs (i.e. antibiotics) that affect the enterohepatic circulation or liver enzymes. In circulation EE2 is almost fully bound to plasma albumin. It is metabolized by hydroxylation of the aromatic ring and excreted in both feces and urine, in part as glucuronide and sulfate conjugate.

EE2 is hormonally effective by activating the estrogen receptor and thus is an estrogen. It finds its most common use in the estrogen-progestin combination preparations of oral contraceptives. Over time, formulations have decreased the EE2 dose from as high as 100 μg to as low as 10 μg in LoLoestrin Fe.Safe Health EE2 Estrogen Steroid Medical Raw Hormone Powders Einecs 200-350-6

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