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CAS 13647-35-3 Pharmaceutical Raw Materials , Trilostane Pharmaceutical Powder

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CAS 13647-35-3 Pharmaceutical Raw Materials , Trilostane Pharmaceutical Powder

China CAS 13647-35-3 Pharmaceutical Raw Materials , Trilostane Pharmaceutical Powder supplier
CAS 13647-35-3 Pharmaceutical Raw Materials , Trilostane Pharmaceutical Powder supplier CAS 13647-35-3 Pharmaceutical Raw Materials , Trilostane Pharmaceutical Powder supplier

Large Image :  CAS 13647-35-3 Pharmaceutical Raw Materials , Trilostane Pharmaceutical Powder

Product Details:

Place of Origin: China
Brand Name: YIHAN
Certification: ISO,GMP,KOSHER
Model Number: Trilostane

Payment & Shipping Terms:

Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: safe and Professional Disguised Package
Delivery Time: within 24 hours After Payment
Payment Terms: T/T,Western Union,bank transfer,MoneyGram
Supply Ability: 500Ton/Month
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Detailed Product Description
CAS: 13647-35-3 MF: C20H27NO3
MW: 329.43 EINECS: 237-133-0
Usage: An Inhibitor Of Steroid Biosynthesis. Used As An Adrenocortical Suppressant. Used In The Treatment Of Breast Cancer . Antifungal, Inhibits Mitosis In Metaphase Sulphated Ash: 0.06%
Loss On Drying: 0.30% Assay(on Dried Basis): 99.5%

 

 

CAS 13647-35-3 Pharmaceutical Raw Materials , Trilostane Pharmaceutical Powder

 

Detailed Product Description

 

Product Name:

     Trilostane

Alias:

TRILOSTANE

CAS NO:

13647-35-3

Purity:

99%

Apperance:

white crystalline powder

Application:

Pharmaceutical  intermediates

 

 

1. Quick Details:

 

Product name: Trilostane
Other Names: 4a,5a,17b)-3,17-Dihydroxy-4,5-epox
CAS: 13647-35-3
EINECS: 237-133-0
MF: C20H27NO3
MW: 329.43
Appearance: White to off-white power
Purity: 99% min
Density: 1.28g/cm3
Melting Point(ºC): 264ºC
Boiling Point(ºC): 497.8°C at 760 mmHg
Flash Point(ºC): 254.8°C
Grade Standard: Medicine Grade
Usage: Anti-tumor drugs and immunosuppressants
Deliver methods: By express (door to door)
Deliver time: About 5 days

 

2. What is Trilostane?

Trilostane is an enzyme inhibiting medication. Its principal use is in the treatment of canine Cushing's disease. In some cases, trilostane may also be an appropriate treatment for horses, cats and other conditions.

It was withdrawn from human use in the United States market in April 1994. The drug was previously available in the United Kingdom for use in humans under the brand name Modrenal for the treatment of Cushing's disease and for breast cancer. It was approved in the United States in 2008 for the treatment of Cushing's disease (hyperadrenocorticism) in dogs under the brand name Vetoryl.[8] It was available by prescription in the UK under the Vetoryl brand name for some time before it was approved in the US. The drug is also used to treat the skin disorder Alopecia X in dogs.It is also the first drug approved to treat both pituitary- and adrenal-dependent Cushing's in dogs. This prescription drug works by stopping the production of cortisol in the adrenal glands.

 

3. Mechanism of action/Effect:

Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.

 

4. Veterinary Medicine:Dogs and Cushing's Disease

Cushing's disease is most common in smaller dogs. Signs of Cushing's syndrome may include increased appetite, thirst and urination, hair loss, bald patches and an enlarged abdomen. Without treatment, dogs can develop weak and calcified skin patches, hepatopathy and frail abdominal muscles.

Canine Cushing's disease is caused by excess secretion of the adrenocorticotropic hormone, which elevates cortisol levels. Most dogs that develop Cushing's disease have pituitary dependant hyperadrenocorticism (PDH). Those who do not have Cushing's because of PDH have an adrenocortical tumor, which may be benign or malignant. Whether the result of an adrenal or pituitary tumor, Cushing's disease interferes with biological mechanisms that normally function to regulate cortisol blood levels.

 

5. Trilostane: Other Uses in Veterinary Medicine

In addition to treatment for pituitary dependant hyperadrenocorticism, adrenocortical tumors and Cushing's disease, Trilostane may be used to treat dogs with Alopecia X. Advancements in veterinary medicine have also led to substantial groundwork in the use of trilostane for treating horses with Cushing's.

Additionally, while PDH in felines is rare, trilostane may be a chosen form of therapy. However, trilostane has revealed to be a less successful form of treatment for cats.

 

6. Trilostane Side Effects:

Trilostane is well tolerated in most dogs. Transient biochemical abnormalities include mild hyperkalemia, azotemia, hyperbilirubinemia and hypercalemia.
There may be a subset of dogs in which trilostane blocks the synthesis of mineralocorticoids more effectively than gluccocorticoids. This group of dogs is at increased risk for adverse reactions including dehydration, weakness, hyponatremia and hypokalemia.
Side effects include lethargy, weakness, vomiting, anorexia and diarrhea. Rare fatalities have been reported. The incidence of side effects is higher with once a day dosing.

7. Our Adwantage:

High quality with competitive price:
1) Standard: Enterprise Standard
2) All Purity:>=99%
3) We are manufacturer and can provide high quality products with factory price.

Fast and safe delivery:
1) Parcel can be sent out in 24 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate: >=99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.


CAS 13647-35-3 Pharmaceutical Raw Materials , Trilostane Pharmaceutical Powder

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