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Toremifene Citrate Anti Estrogen Steroids Hormonal Antitumor APIs For Cancer Treatment

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Toremifene Citrate Anti Estrogen Steroids Hormonal Antitumor APIs For Cancer Treatment

China Toremifene Citrate Anti Estrogen Steroids Hormonal Antitumor APIs For Cancer Treatment supplier
Toremifene Citrate Anti Estrogen Steroids Hormonal Antitumor APIs For Cancer Treatment supplier Toremifene Citrate Anti Estrogen Steroids Hormonal Antitumor APIs For Cancer Treatment supplier

Large Image :  Toremifene Citrate Anti Estrogen Steroids Hormonal Antitumor APIs For Cancer Treatment

Product Details:

Place of Origin: China
Brand Name: YIHAN
Certification: GMP, HSE, ISO 9001, USP, BP
Model Number: Toremifene Citrate

Payment & Shipping Terms:

Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: aluminium foil bag or as required (simulate package )
Delivery Time: 1-3 days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 551kg / month
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Detailed Product Description
CAS: 89778-27-8 State: Powder
Molecular Formula: C26h28clno.C6h8o7 Molecular Weight: 598.09
Boiling Point: 535.1 º C At 760 MmHg Melting Point: 158-164 º C
Degree: <0.4% Heavy Metals: <10PPm
Assay(by HPLC): 99.64%

Toremifene Citrate Anti Estrogen Steroids Hormonal Antitumor APIs For Cancer Treatment

 

Quick Detail:

 

An estrogen agonist/antagonist that blocks the growth-stimulating effects of estrogen in the tumor.

 

Description:

Toremifene citrate

Product Name: Toremifene citrate

CAS No.: 89778-27-8

M.F.: C32H36ClNO8

M.W.: 598.08

Packing: 1kg/foil bag

Assay: 99%

Melting Point: 158-164℃

Appearance: White powder

Toremifene Citrate Anti Estrogen Steroids Hormonal Antitumor APIs For Cancer Treatment

 

Specifications:

 


Description
White or Almost White Crystalline Powder white powder
Identification A.B. Positive
Assay 97.0~103.0% 99.0%
Specific Rotation +101°~+105° +102.6°
Loss On Drying 1.0%max 0.28%
Organic Volatile Impurities meets the requirement. Conforms
Related Substances meets the requirement. Conforms
Residual Solvents meets the requirement. Conforms
Particle Size 100% ≤ 20 microns

Conforms

 

Applications:

 

Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene citrate is FDA-approved for use in advanced (metastatic)breast cancer. It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.

 

Used for Metastatic breast cancer in postmenopausal women.

PO 60 mg once daily with or without food. Treatment is generally continued until disease progression is observed.

 

Function:


Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene citrate is FDA-approved for use in advanced (metastatic) breast cancer. It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.
It has already been covered that Toremifene is a SERM, and serves to block Estrogen at various receptor sites in certain tissues within the body (breast tissue in particular). As a layman explanation, Toremifene pretends to be a 'fake' Estrogen that occupies Estrogen receptors within breast tissue. With these receptors occupied by Toremifene, real Estrogen cannot perform their jobs there. Toremifene does not reduce total blood plasma levels of Estrogen. In addition to being antagonistic to Estrogen receptors in breast tissue, it is also antagonistic to Estrogen at the hypothalamus gland (this essentially 'tricks' the hypothalamus into thinking there is little or no circulating Estrogen levels in the body, causing it to increase its manufacture of Testosterone so that it can utilize aromatization to restore these levels.
Toremifene is also agonistic to Estrogen receptors in other tissues in the body (within the liver in particular). This means that whileToremifene will act as an anti-estrogen in breast tissue and the hypothalamus, it will act as an Estrogen within the liver. This can have beneficial impacts especially during an anabolic steroid cycle, such as improving and shifting cholesterol levels into a more favorable range.

 

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