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13647-35-3 COA Raw Steroid Powders Trilostane For Breast Cancer / Canine Cushing′s Disease Treatment

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13647-35-3 COA Raw Steroid Powders Trilostane For Breast Cancer / Canine Cushing′s Disease Treatment

China 13647-35-3 COA Raw Steroid Powders Trilostane For Breast Cancer / Canine Cushing′s Disease Treatment supplier
13647-35-3 COA Raw Steroid Powders Trilostane For Breast Cancer / Canine Cushing′s Disease Treatment supplier 13647-35-3 COA Raw Steroid Powders Trilostane For Breast Cancer / Canine Cushing′s Disease Treatment supplier

Large Image :  13647-35-3 COA Raw Steroid Powders Trilostane For Breast Cancer / Canine Cushing′s Disease Treatment

Product Details:

Place of Origin: China
Brand Name: YIHAN
Certification: COA,GMP,SGS,ISO,KOSHER
Model Number: Trilostane

Payment & Shipping Terms:

Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Very discreet or as required
Delivery Time: Within 24hours after receiving the payment
Payment Terms: Western Union, L/C, D/A, D/P, T/T, MoneyGram
Supply Ability: 5000kg/ month
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Detailed Product Description
Product Name: Trilostane CAS No: 13647-35-3
Appearance: White Powder Assay: 99%
Usage: For Breast Cancer Treatment Molecular Formula: C42h68n2o2
Molecular Weight: 633.0015 Einecs: 237-133-0

13647-35-3 COA Raw Steroid Powders Trilostane For Breast Cancer / Canine Cushing′s Disease Treatment

 

Quick Detail:

Trilostane
Synonym: Vetoryl
CAS Registry Number: 13647-35-3
Alias: 99%
Einecs No: 237-133-0
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation
Appearance: White crystalline powder
Manufacturer: Yuan Cheng
Molecular Weight: 329.4333
Molecular Formula: C20H27NO3
Melting point: 264° C
Boiling point: 497.8° C at 760 mmHg
Refractive index: 1.61
Flash point: 254.8° C
Vapour Pressur: 5.39E-12mmHg at 25° C
Lead time: 1-2 days upon receipt of payment
Delivery Term: Products below 200Kg by air; Over 200Kg by ship
Delivery Time: Average 6 days by air; 15 days by ship
Usage: Trilostane can inhibit cortical hormone in the process of synthesis of 3 beta dehydrogenase, 
make the cortisol, aldosterone synthesis decreased, clinically used in the treatment of Cushing syndrome
 (hypercortisolism) and primary aldosteronism. This product also had significantly effect to decreased serum testosterone level.

 

Description:

Trilostane is an inhibitor of isoforms 3β-HSD and 3β-HSD2 of the enzyme 3β-hydroxysteroid dehydrogenase,
 which plays a role in adrenal steroid biosynthesis. Investigators believe 
that Arg195 in 3β-HSD versus Pro195 in 3β-HSD2 attributes to the competitive inhibition of 
3β-HSD, but not 
3βHSD2 by Trilostane. Research shows that trilostane is effective in suppressing the intracellular
 production oin LNCaPFGC prostate cancer cells and inhibiting cortisol biosynthesis in the human 
adrenal gland. This product serves as a useful tool in steroid biosynthesis research.

 

 

Application:

Trilostane can suppress cortical hormone synthesis process of 3 beta dehydrogenase, make cortisol, 
aldosterone synthesis reduce, clinical used in the treatment of Cushing syndrome(cortisol increase 
disease) and primary aldosteronism,the effect is not good than testosterone metyrapone. This product 
has significantly reduced blood testosterone level role, may relevant to its inhibit synthetic.

 

 

Specifications(COA and HPLC):
 



Test Items

Specification

Test Results

Appearance

white oralmost white,crystalline powder

Conform

Solubility

Freely soluble in water,practically insoluble or very slightly soluble in alcohol and in methylene chloride.

Conform

Identification

A

The UV absorption spectrum of the sample shows an absorption maximum at 276nm.The specific absorbance at the Maximum is55 to 64.

Conform

B

Infraed absorption spectrophotometry.

Conform

C

Chromatogram obtained with test solution (b) is similar in position color & size to the principal spot in the chromatogram obtained with the reference solution.

Conform

D

An orange-red color develop in methylene chloride layer.

Conform

E

It geves reaction (a) of sulphates.

Conform

Appearance of solution

Solution S is clear and not more intensely coloured than reference solution in BY6.

Conform

Optical rotation

negative 0.10° to +0.10°determined on solution S.

+0.01°

Acidity or alkalinity

NMT 0.4ml of 0.01M HCL is required to change the color of the indicator to red.

Conform

Related substances

Impurity J ≤0.20%

Conform

Any other impurity ≤0.30%

Conform

Total impurity ≤1.0%

Conform

Boron

≤50ppm

Conform

Sulphated ash

≤0.10%

0.06%

Loss on drying

≤0.5%

0.30%

Assay(on dried basis)

98.0~101.0%

99.5%

Conclusion

The test results above BP2009
 

 

13647-35-3 COA Raw Steroid Powders Trilostane For Breast Cancer / Canine Cushing′s Disease Treatment

Trilostane Specifications:

Test Items Specification Test Results
Appearance white oralmost white,crystalline powder Conform
Solubility Freely soluble in water,practically insoluble or very slightly
soluble in alcohol and in methylene chloride.
Conform
Identification A The UV absorption spectrum of the sample shows
an absorption maximum at 276nm.The specific
absorbance at the Maximum is55 to 64.
Conform
  B Infraed absorption spectrophotometry. Conform
  C Chromatogram obtained with test solution (b) is
similar in position color & size to the principal spot in the
chromatogram obtained with the reference solution.
Conform
  D An orange-red color develop in methylene chloride layer. Conform
  E It geves reaction (a) of sulphates. Conform
Appearance of solution Solution S is clear and not more intensely coloured than
reference solution in BY6.
Conform
Optical rotation negative 0.10° to +0.10°determined on solution S. +0.01°
Acidity or alkalinity NMT 0.4ml of 0.01M HCL is required to change the color
of the indicator to red.
Conform
Related substances Impurity J ≤0.20% Conform
  Any other impurity ≤0.30% Conform
  Total impurity ≤1.0% Conform
Boron ≤50ppm Conform
Sulphated ash ≤0.10% 0.06%
Loss on drying ≤0.5% 0.30%
Assay(on dried basis) 98.0~101.0% 99.5%

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Yihan Industrial Co.,Ltd.

Contact Person: Anna

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