Payment & Shipping Terms:
|Product Name:||EPO||Packing:||Discreet Packing, Or As Request|
|Suitable For:||Adult||Other Product:||Steroids Powder, Steroids Inject Liquid, Sarms , HGH|
|Synonyms:||ERYTHROPOIETIN;Erythropoietin human,EPO;ANTI-ERYTHROPOIETIN(N-TERMINAL) antibody produced in rabbit;ANTI-ERYTHROPOIETIN(C-TERMINAL) antibody produced in rabbit;INN=Epoetin;ERYTHROPOIETIN RAT;EPO;erythropoietin from human urine*approx 100 units|
|Product Categories:||Peptides;monoclonal antibody|
When exogenous EPO is used as a performance-enhancing drug, it is classified as an erythropoiesis-stimulating agent (ESA). Erythropoietin, or its alternative erythropoetin or EPO, is a glycoprotein hormone that controls erythropoiesis, or red blood cell production. It is a cytokine for erythrocyte (red blood cell) precursors in the bone marrow.
Also called hematopoietin or hemopoietin, it is produced by the peritubular capillary endothelial cells in the kidney, and is the hormone that regulates red blood cell production. It also has other known biological functions. For example, erythropoietin plays an important role in the brain's response to neuronal injury. EPO is also involved in the wound healing process.
Primary role in red cell blood line
Erythropoietin has its primary effect on red blood cells by promoting red blood cell survival through protecting these cells from apoptosis. It also cooperates with various growth factors involved in the development of precursor red cells. Specifically, the colony forming unit-erythroid (CFU-E) is completely dependent on erythropoietin. The burst forming unit-erythroid (BFU-E) is also responsive to erythropoietin.
Under hypoxic conditions, the kidney will produce and secrete erythropoietin to increase the production of red blood cells by targeting CFU-E, pro-erythroblast and basophilic erythroblast subsets in the differentiation.
It has a range of actions including vasoconstriction-dependent hypertension, stimulating angiogenesis, and inducing proliferation of smooth muscle fibers. It has also been shown that erythropoietin can increase iron absorption by suppressing the hormone hepcidin.
Erythropoietin is available as a therapeutic agent produced by recombinant DNA technology in mammalian cell culture. It is used in treating anemia resulting from chronic kidney disease and myelodysplasia, from the treatment of cancer (chemotherapy and radiation). Current research suggests that, aminoacid R103 to E mutation in Erythropoietin makes it Neuroprotective and non-erythropoietic.
Erythropoietins available for use externally for medical purpose are produced using recombinant DNA technology. Isolation and synthesis of this hormone is very useful for performance enhancing purpose. Structurally this hormone is a single chain of polypeptide containing 165 amino acids. Exogenous EPO taken for strength and performance enhancing purpose is classified as erythropoiesis-stimulating agent (ESA) but can be detected in blood tests due to difference from endogenous one. Hemax (EPO) became famous in 1998 after many positive doping results during Tour de France.
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