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|Product Name:||Tetracaine||Advantages:||Reship Policy|
|Type:||Pharmaceutical Intermediate||Appearance:||White Solid|
|Synonyms:||2-(Dimethylamino)ethyl 4-(butylamino)benzoate;2-(Dimethylamino)ethyl p-(butylamino)benzoate;2-Dimethylaminoethylester kyseliny p-butylaminobenzoove;2-dimethylaminoethylesterkyselinyp-butylaminobenzoove;2-dimethylaminoethylp-butylaminobenzoate;4-(butylamino)-benzoicaci2-(dimethylamino)ethylester;amethocaine;Anetain|
|Product Categories:||Pharmaceutical Intermediates-;-;API;medical intermediate|
etracaine is a local anesthetic or numbing medicine that is used to numb the throat, eyes, or nose. Normally, the drug is administered before starting a surgery to decrease pain from the procedure. Tetracaine is applied to the eyes 30 minutes before the start of an intravenous and its effects can last up to 15 minutes.
Tetracaine was developed to address the low potency andshort duration of action of procaine and chloroprocaine. The addition of the butyl side chain on the para nitrogen increasesthe lipid solubility of the drug and enhances the topical potencyof tetracaine. The plasma half-life is 120 to 150 seconds.Topically applied tetracaine to unbroken skin requires 30 to 45minutes to confer topical anesthesia. Tetracaine 4% gel is superiorthan eutectic mixture with lidocaine (EMLA) (an emulsionof lidocaine and prilocaine) in preventing pain associatedwith needle procedures in children. Tetracaine metabolism issimilar to procaine ester metabolism yielding parabutylaminobenzoicacid and dimethylaminoethanol and conjugatesexcreted in the urine. The pKa of the dimethylated nitrogen is8.4 and tetracaine is formulated as a hydrochloride salt with apH of 3.5 to 6.0. The increased absorption from topical siteshas resulted in reported toxicity. Overdoses of tetracaine mayproduce central nervous system (CNS) toxicity and seizure activitywith fatalities from circulatory depression reported.No selective cardiac toxicity is seen with tetracaine althoughhypotension has been reported. Tetracaine is employed for infiltrationanesthesia, spinal anesthesia, or topical use.
Tetracaine acts by blocking the nerve systems. It does this by blocking the sodium ion channels needed for the conduction and initiation of neural impulses, thereby affecting the local anesthesia. Tetracaine acts by altering the function of calcium release channels that controls the release of calcium frim intracellular cells.
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
use:Used for mucosal epidermal anesthesia, nerve tissue anesthesia, epidural anesthesia and Subarachnoid space anesthesia.
In the manufacture of pharmaceutical preparation for external use, to relieve the pain of drugs or medication lesions pain.
Local Anesthetic Drugs we supply
|Procaine Base||CAS 59-46-1a|
|Lidocaine HCl||CAS 73-78-9|
|Lidocaine Hydrochloride||CAS 51-05-8|
|Xylocaine Lidocaine||CAS 137-58-6|
|Tetracaine HCl||CAS 136-47-0|
|Propitocaine Hydrochloride||CAS 1786-81-8|
|Aarticaine Hydrochloride||CAS 23964-57-0|
|Procaine Hydrochloride||CAS 51-05-8|
|Tetracaine hydrochloride||CAS 136-47-0|
|Lidocaine Base||CAS 137-58-6|
|Dyclonine hydrochloride||CAS 536-43-6|
|Tetracaine Base||CAS 94-24-6|
|Dibucaine Hydrochloride||CAS 61-12-1|
|Proparacaine Hydrochloride||CAS 5875-06-9|
|Ropivacaine Hydrochloride||CAS 98717-15-8|
|Bupivacaine Hydrochloride||CAS 14252-80-3|
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