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|Product Name:||Procaine HCl||Advantages:||Reship Policy|
|Type:||Pharmaceutical Intermediate||Appearance:||White Powder|
|Full Name:||Procaine Hydrochloride|
|Product Name:||Procaine hydrochloride|
|Product Categories:||-;API-;Sodium channel;APIS;Anesthetics;Pharmaceutical intermediate;Pharmaceutical|
Procaine hydrochloride is a topical anesthetic, which can block the nerve fiber conduction temporarilyand has a narcotic effect,strong effect, low toxicity, and non-addictive, but on the skin, mucosal penetration is weak, unsuitable for surface anesthesia, patients are used for infiltration, conduction and spinal anesthesia.
White fine needle crystal or crystalline powder at room temperature, no smell, taste slightly bitter and Ma, soluble in water, soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. Procaine hydrochloride ester bond structure can be hydrolyzed to produce amino acid and diethylaminoethanol, under certain conditions, the amino acid may be further decarboxylated toxic aniline.
The structure of procaine hydrochloride with aromatic primary amino, easy oxidation discoloration pH, temperature, UV, oxygen and metal ions can accelerate the oxidation discoloration. The aqueous solution was stable in pH3.0~5. So preparation of procaine hydrochloride injection, it generally takes add acid to regulate pH 3.3 to 5.5, and strictly control the sterilization temperature and time. to 100 ℃ steam sterilization 30min circulation is appropriate, and should pay attention to shading, sealed save.
The product structure of aromatic primary amino group in dilute hydrochloric acid can generate diazonium salt with sodium nitrite, coupling reaction occurs when add alkaline β-naphthol, generating azo compounds scarlet.
The above information is edited by the chemicalbook of Kui Xiongfeng.
Procaine HCl is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine. It acts mainly by being a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.
Procaine HCl is indicated for the production of local or regional analgesia and anesthesia by local infiltration and peripheral nerve block techniques.
|Product name||Procaine Hydrochloride|
|Appearance||White crystalline powder|
|Assay (C13H20N2O2·HCl)||99.0% to 101.0%||99.5%|
|Solution Appearance||Clear and colorless||Confirm|
|Related impurities||impurity A:≤0.01%||0.002%|
|Single unspecified impurity: ≤0.1%||0.03%|
|Total impurity: ≤0.5%||0.19%|
|Pain Killer Product||Cas No|
|Procaine HCL(10-40 mesh)||51-05-8|
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