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|Product Name:||Lidocaine HCL||Advantages:||Reship Policy|
|Type:||Pharmaceutical Intermediate||Appearance:||White Powder|
|Full Name:||Lidocaine Hydrochloride|
|Product Name:||Lidocaine hydrochloride|
|Synonyms:||Lidocaine hydrochloride 2-(Diethylamino)-N-(2,6-dimethylphenyl)-acetamide hydrochloride;99% Lidocaine Hydrochloride Pharmaceutical Raw Materials 73-78-9 Lidocaine HCl CAS NO.73-78-9;2-DIETHYLAMINO-N-(2'6'-DIMETHYLPHENYL)ACETAMIDE HCL;2-DIETHYLAMINO-N-[2,6-DIMETHYLPHENYL]ACETAMIDE HCL;A-(DIETHYLAMINO)-2 6-DIMETHYLACETANILIDE H;Lidocaine hydrochloride cas 73-78-9 (skype:lisa_21819);ALPHA-(DIETHYLAMINO)-2',6'-ACETOXYLIDIDE HYDROCHLORIDE;A-(DIETHYLAMINO)-2 6-DIMETHYLACETANILIDE HYDROCHLORIDE|
|Product Categories:||API-;Pharma materials;-;API;Pharmaceutical intermediates;Others;Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Aromatics;Research Chemical|
Lidocaine hydrochloride is a local anesthetic and antiarrhythmic drug. It is clinically used for infiltration anesthesia, epidural anesthesia, surface anesthesia (including in the thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve conduction block. The drug can also be used for acute myocardial infarction after ventricular premature beats and ventricular tachycardia, and for digitalis poisoning, cardiac surgery and ventricular arrhythmias caused by cardiac catheterization. But it is usually ineffective for supraventricular arrhythmias.
Lidocaine hydrochloride is an amide local anesthetic. After blood absorption or intravenous administration, the drug has obvious excitement and inhibition of biphasic effects for the central nervous system, and no excitement of the pioneer. With the dose increased, the role or toxicity increased, there is an anti-convulsive effect with sub-poisoning plasma concentration; Blood concentration of more than 5μg • ml-1 can occur convulsions. Lidocaine hydrochloride in low doses can promote outflow of K+ in cardiomyocytes, reduce myocardial autonomy, and has antiarrhythmic effects. In the treatment dose, lidocaine hydrochloride has no significant effect for the electrical activity of cardiomyocytes, atrioventricular conduction and myocardial contraction. Increased plasma concentration may cause slowing of heart conduction, atrioventricular block, inhibition of myocardial contractility and decreased cardiac output.
Lidocaine hydrochloride is characterized by strong penetration, strong dispersion, rapidly onset. The anesthetic performance is twice that of procaine and the toxicity is1. There is an anesthetic effect after 5 minutes treatments, and anesthesia can last 1 to 1.5 hours, 50% longer than procaine. The drug is effective on the heart of the disease or arrhythmia caused by cardiac glycoside, but on the supraventricular tachycardia is poor. This product is fast and oral ineffective, with short duration, and often used as intravenous administration.
The incidence of adverse effect with lidocaine hydrochloride was about 6.3%. Most adverse effects are dose dependent. Adverse effects are drowsiness, dizziness, nausea, vomiting, burnout, euphoria, insanity, muscle convulsions, syncope, blurred vision, confusion and difficulty breathing. Large doses lead to severe sinus bradycardia, cardiac arrest, severe atrioventricular block and weakened myocardial contractility, reduced blood pressure and so on. Excess concentrations of lidocaine hydrochloride in the blood cause some problems. For example, atrial conduction slows, atrioventricular blocks (A-V-B), and inhibits myocardial contractility and cardiac output decreases. There are little allergic effects, such as erythema rash, angioneurotic edema and so on.
|Pain Killer Product||Cas No|
|Procaine HCL(10-40 mesh)||51-05-8|
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