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Antineoplastic Medicine Grade Raw Material Ibrutinib CAS 936563-96-1

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Antineoplastic Medicine Grade Raw Material Ibrutinib CAS 936563-96-1

China Antineoplastic Medicine Grade Raw Material Ibrutinib CAS 936563-96-1 supplier
Antineoplastic Medicine Grade Raw Material Ibrutinib CAS 936563-96-1 supplier Antineoplastic Medicine Grade Raw Material Ibrutinib CAS 936563-96-1 supplier Antineoplastic Medicine Grade Raw Material Ibrutinib CAS 936563-96-1 supplier

Large Image :  Antineoplastic Medicine Grade Raw Material Ibrutinib CAS 936563-96-1

Product Details:

Place of Origin: China
Brand Name: YIHAN
Certification: GMP,USP,BP,ISO 9001
Model Number: 936563-96-1

Payment & Shipping Terms:

Minimum Order Quantity: 10G
Price: USD0.1-2 +g
Packaging Details: Discreet Package or as Required.
Delivery Time: 3-5 work days
Payment Terms: MoneyGram,Paypal, T/T, Western Union
Supply Ability: 5000kg/Month
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Detailed Product Description
Product Name: Ibrutinib Advantages: Reship Policy
Suitable For: Adult CAS: 936563-96-1
Type: Pharmaceutical Intermediate Appearance: White Powder
Grade: Pharmaceutcial Grade

1. Basic Info

CAS No.:
936563-96-1

Other Names:

Ibrutinib

MF:

Ibrutinib

EINECS No.:

936563-96-1

Place of Origin:

shanxi , China (Mainland)

Type:

Antineoplastic Agents

Grade Standard:

Medicine Grade

Brand Name:

YIHAN

Model Number:

Ibrutinib 936563-96-1

Purity:

98% Ibrutinib

Chemical Name:

Ibrutinib

Appearance:

White Solid

Identification:

should conform

Composition Test:

should conform

PH:

6.5~7.5

Loss on Drying:

NMT5.0%

Usage:

antineoplastics

 


Function :

Ibrutinib is a cancer drug that targets B-cell malignancies such as certain leukemias and lymphomas.

 

Antineoplastic Medicine Grade Raw Material Ibrutinib CAS 936563-96-1

 

 

2. Descriptions:

 

Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.PCI-32765 (Ibrutinib) is a selective and irreversible pyrrolopyrimidine-based inhibitor of BTK with IC50 of 0.5 nM. [1] PCI-32765 binds irreversibly to Cys-481 in BTK and thus is only active with other kinases with such a modifiable cysteine residue. In DOHH2 cells, in which the BCR pathway can be activated by anti-IgG, PCI-32765 inhibits autophosphorylation of BTK (IC50, 11 nM), BTK's physiological substrate, PLCg (IC50, 29 nm), and downstream ERK (IC50, 13 nm).

 

Ibrutinib is a kind of Bruton tyrosine kinase (BTK) inhibitor, it could be used for the treatment of chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). MCL and CLL are belonged to the B-cell non-Hodgkin's lymphoma, which is difficult to cure and easy to recurrent. Common chemical immunotherapy does not have the targeting, often occurs 3 or 4 adverse reactions.

Ibrutinib and B lymphocytes could target with BTK which is necessary for formation, differentiation, and transmission of information, inhibit BTK activity irreversibly, and inhibit tumor cell proliferation and survival effectively. Ibrutinib could be rapidly absorbed after oral administration, during 1~2h reach maximum blood concentration, adverse reactions belong to one or two, therefore, Ibrutinib will become a new choice of treatment of CLL and MCL.

 

 

3. detail

 

 

ITEMS SPECIFICATION TESTRESULTS
Appearance Off-white or white powder Conforms
Identification HPLC,NMR;LC-MS Conforms
Related substances Individual impurity≤0.5% 0.09%
Total impurities≤1.0% 0.20%
Loss on drying ≤0.5% 0.3%
Residue on ignition ≤0.1% 0.04%
Heavy metals ≤10ppm Conforms
Assay ≥98.0 % 99.1%

 

 

 

other product : 

 

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Lapatinib Ditosylate 388082-77-7
Gefitinib 184475-35-2
Dasatinib 302962-49-8
Crizotinib 877399-52-5
Ibrutinib 936563-96-1
BIBW2992 DiMaleate 850140-73-7
Cabozantinib Malate 1140909-48-3
lenvatinib Mesylate 857890-39-2
Ceritinib (LDK378) 1032900-25-6
Cabozantinib 849217-68-1
lenvatinib 417716-92-8
Imatinib mesylate 220127-57-1

 

 

About us:

we, Yihan Industrial Co., Ltd from china are specilized in steroids powder , semi-finished liquids , peptides , Sarm powder,HGH,HCG,Finished Liquid and other pharmaceutical materials for many years .

If you have any further questions or need a sample,Please do not hesitate to contact me.Thank you!

Juddy Email: sales01@yihanind.com
Phone(Whatsapp/ Wechat/Skype) +8613243765351
 

 

 

 

 
 
 

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Tel: +8613243765351

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