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White Peptides Steroids Myostatin / GDF-8 / Growth Differentiation Factor 8 CAS 901758-09-6

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White Peptides Steroids Myostatin / GDF-8 / Growth Differentiation Factor 8 CAS 901758-09-6

China White Peptides Steroids Myostatin / GDF-8 / Growth Differentiation Factor 8 CAS 901758-09-6 supplier
White Peptides Steroids Myostatin / GDF-8 / Growth Differentiation Factor 8 CAS 901758-09-6 supplier White Peptides Steroids Myostatin / GDF-8 / Growth Differentiation Factor 8 CAS 901758-09-6 supplier White Peptides Steroids Myostatin / GDF-8 / Growth Differentiation Factor 8 CAS 901758-09-6 supplier

Large Image :  White Peptides Steroids Myostatin / GDF-8 / Growth Differentiation Factor 8 CAS 901758-09-6

Product Details:

Place of Origin: China
Brand Name: YIHAN
Certification: ISO 9001, USP,GMP
Model Number: GDF-8

Payment & Shipping Terms:

Minimum Order Quantity: 1 Box
Price: USD$3-6/Vial
Packaging Details: 5mg/Vial or as required
Delivery Time: 1-3 work days
Payment Terms: Western Union, MoneyGram, T/T, Trade assurance
Supply Ability: 1000boxes/Month
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Detailed Product Description
Product Name: GDF-8 Packing: Discreet Packing, Or As Request
Assays: 99%min State: Peptides
Suitable For: Adult Specification: 1mg/vial
Markets: Global Appearance: White Lyophilized Powder
Policy: Reship Policy Other Product: Steroids Powder, Steroids Inject Liquid, Sarms , HGH

Injectable Growth Hormone Peptides Myostatin Peptide GDF-8 Lyophilized Powder
 
Quick Detail:

 

Product Name

GDF-8
 

Chemical Name

Growth Differentiation Factor 8
 

Other Names

Myostatin
 

CAS

901758-09-6
 

MF

C221H366N72O67S
 

Appearance

White powder
 

Dry

Freeze
 

Purity

>98%

 

 
product descroption: 
 

Myostatin / GDF-8 is a protein that in humans is encoded by the MSTN gene. It isproduced primarily in skeletal muscle cells, circulates in the blood and acts on muscle tissue. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide acting as a negative regulator of myostatin. Recombinant human Myostatin Propeptide is a non-glycosylated protein, containing 244 amino acids, with a molecular weight of 27.8 kDa. Our Myostatin 1mg is Tagged. The tags are chains/pile of amino acids/proteins, it is foreign protein that will cause immunization reaction in most cases.

Myostatin / GDF-8 is a member of the TGF beta superfamily of proteins. Human myostatin consists of two identical subunits, each consisting of 109 amino acid residues. Its total molecular weight is 25.0 kDa. The protein is made in an inactive form. For it to be activated, a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the now-active COOH-terminal dimer

 

Myostatin (GDF-8) is a member of the transforming growth factor-beta (TGF-beta) superfamily that is highly expressed in skeletal muscle, and myostatin loss-of-function leads to doubling of skeletal muscle mass. Myostatin-deficient mice have been used as a model for studying muscle-bone interactions, and here we review the skeletal phenotype associated with altered myostatin signaling. It is now known that myostatin is a key regulator of mesenchymal stem cell proliferation and differentiation, and mice lacking the myostatin gene show decreased body fat and a generalized increase in bone density and strength.

The increase in bone density is observed in most anatomical regions, including the limbs, spine, and jaw, and myostatin inhibitors have been observed to significantly increase bone formation. Myostatin is also expressed in the early phases of fracture healing, and myostatin deficiency leads to increased fracture callus size and strength. Together, these data suggest that myostatin has direct effects on the proliferation and differentiation of osteoprogenitor cells, and that myostatin antagonists and inhibitors are likely to enhance both muscle mass and bone strength.

 

Application

 

1) The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".

2) Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.

3) Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.
Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition[8] Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.

 
 

COA:

Test Items Specification Results
Description white lyophilized powder white lyophilized powder
Melting Point 191.0~193.0ºC 192ºC
Loss of drying ≤1.0% 0.5%
Heavy Metal ≤20ppm 15ppm
TLC Only one spot Only one spot
Assay ≥99.5% 99.91%
Conclusion It complies with the USP 32.

 

 

Peptide List:

Product Specification
HGH Frag176 191(HGH) 2mg
HGH Frag176 191(HGH) 5mg
TB500 2mg
TB500 5mg
GHRP-2 10mg
GHRP-2 5mg/vial, 10vials/box
GHRP-6 10mg/vial, 10vials/box
GHRP-6 5mg/vial, 10vials/box
CJC1295 With DAC 2mg/vial, 10vials/box
CJC1295 without DAC--MOD GRF(1-29) 2mg/vial, 10vials/box
PT141 (Bremelanotide) 10mg/vial, 10vials/box
Ipamorelin 2mg/vial, 10vials/box
Ipamorelin 5mg/vial, 10vials/box
MGF (Mechano growthfactor) (IGF- IEC) 2mg/vial, 10vials/box
PEG MGF 2mg/vial, 10vials/box
Hexarelin 2mg/vial, 10vials/box
Sermorelin--GRF(1-29) 2mg/vial, 10vials/box
MT1 10mg/vial, 10vials/box
MT2 10mg/vial, 10vials/box
Gonadorelin 2mg/vial, 10vials/box
DSIP 2mg/vial, 10vials/box
Triptorelin/Gnrh Triptoreli 2mg/vial, 10vials/box
selank 5mg/vial, 10vials/box
oxytocin 2mg/vial, 10vials/box
Tesamorelin 2mg/vial, 10vials/box
Aod9604 2mg/vial, 10vials/box
Epithalon 10mg/vial, 10vials/box
BPC157 5mg/vial, 10vials/box
BPC157 2mg/vial, 10vials/box
IGF LR3-1 0.1mg/vial, 10vials/box
IGF LR3-1 1mg/vial, 10vials/box
IGF IDES 1mg/vial, 10vials/box
Follistatin 344 1mg/vial, 10vials/box
GDF-8 1mg/vial, 10vials/box
ACE-031 1mg/vial, 10vials/box
adipotide 2mg/vial, 10vials/box
aicar 50mg/vial, 10vials/box
semax 5mg/vial, 10vials/box
 

About us:
we, Yihan Industrial Co., Ltd from china are specilized in steroids powder , semi-finished liquids , peptides , Sarm powder,HGH,HCG,Finished Liquid and other pharmaceutical materials formany years .
If you have any further questions or need a sample,Please do not hesitate to contact me.Thank you!

 
Juddy Email: sales01@yihanind.com
Phone(Whatsapp/ Wechat/Skype) +8613243765351

 
 White Peptides Steroids Myostatin / GDF-8 / Growth Differentiation Factor 8 CAS 901758-09-6

 

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Contact Person: Juddy Zhang

Tel: +8613243765351

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