Payment & Shipping Terms:
|Product Name:||ACE 031||Assays:||99%min|
|Appearance:||White Lyophilized Powder||Policy:||Reship Policy|
Peptide Human Growth Hormone Peptide Ace 031 Powder 1mg/Vial ACE031 for Bodybuilder Muscle Growth
Unit: 1mg/vial ,10vial/kit
Synonyms:ACE-031, ActRIIb-hFc, ACVR2B, activin receptor type IIB and human immunoglobulin Fc region construct, myostatin inhibitor.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Specificity: The amino acid sequence of the recombinant human ActRIIb-hFc is 100% homologous to the amino acid sequence of the human ActRIIb receptor and immunoglobulin Fc region proteins.
Solubility: Add 1 ml of sterile diluent and let the lyophilized pellet dissolve completely.
Stability: Store lyophilized protein at -20 °C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 °C for a limited period of time. The lyophilized protein remains stable until the expiry date when stored at -20 °C.
Ace-031, also known as ACVR2B, is a soluble form of activin type IIB receptor, which is an inhibitor of myostatin and other naturally occurring proteins that limit muscle growth. This compound was genetically developed to bind to myostatin before it can attach to its receptor and halt muscle growth. The two Biopharma companies that worked on this compound are Acceleron and Shire.
Development of ACE-031 is fully discussed in Diverting an Unwanted Protein, in the April 2011 issue of Quest, MDA's quarterly research and health magazine.
Companies hope to resume ACE-031 testing after safety issues fully explored
Acceleron and Shire are completing studies of ACE-031 in rats and monkeys and will analyze the human and animal data to gain an understanding of the observed adverse events. The companies say they hope to resume testing ACE-031 in humans after these analyses have been obtained and reviewed by the U.S. Food and Drug Administration (FDA) and Health Canada.
Acceleron and Shire issued the following statement on April 21:
"In an effort to keep the Duchenne muscular dystrophy community informed, Acceleron and Shire wish to provide an update about the status of the ACE-031 clinical program.
"During the course of clinical trials in healthy adults and in DMD boys, some participants experienced minor nosebleeds, gum bleeding, and/or small dilated blood vessels within the skin. These events all resolved fully upon discontinuation of treatment.
"By themselves, the minor bleeding events and dilated blood vessels were not considered to be a serious safety concern for study subjects.
"However, based on review of these safety data with the FDA and Health Canada, Acceleron has terminated the A031-03 DMD study and has suspended enrollment and dosing in the follow-on extension study A031-06.
"Acceleron and Shire remain committed to the global DMD clinical program and the development of ACE-031. To that end, it is our intention to start new studies of ACE-031 in DMD with appropriate safety monitoring following discussions with regulatory agencies.
ACE-031 belongs to class of proteins of TGF-beta super family that regulate muscle growth.
ACE-031 acts on the molecular switches of these molecules and promote muscle growth. In
experimental studies, ACE-031 promotes muscle growth and inhibits ActRIIB receptor signaling.
In pre-clinical studies, administration of ACE-031 for two weeks increased skeletal muscle
density, decreased leptin levels, and increased adiponectin.
Some bodybuilders use ACE-031 to promote muscle growth and to improve lean muscle. No
serious adverse events were reported after ACE-031. Most of the common adverse events are
mild and tolerable. The polypeptide contains 368 amino acid molecules, which forms a very large
polypeptide complex. Muscle growth is regulated by the production of amino acids , and TGF
beta protein super family is mainly the regulator as indicated earlier the on and off switch
mechanism is essential for muscle production. When ActRIIB receptors interact with the GDF-8, it
sends an on signal, which in turn promotes muscle growth
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