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|Usage:||An Inhibitor Of Steroid Biosynthesis. Used As An Adrenocortical Suppressant. Used In The Treatment Of Breast Cancer . Antifungal, Inhibits Mitosis In Metaphase||Sulphated Ash:||0.06%|
|Loss On Drying:||0.30%||Assay(on Dried Basis):||99.5%|
Pharma Raw Materials,
CAS 13647-35-3 Pharmaceutical Raw Materials , Trilostane Pharmaceutical Powder
Detailed Product Description
white crystalline powder
1. Quick Details:
|Appearance:||White to off-white power|
|Boiling Point(ºC):||497.8°C at 760 mmHg|
|Grade Standard:||Medicine Grade|
|Usage:||Anti-tumor drugs and immunosuppressants|
|Deliver methods:||By express (door to door)|
|Deliver time:||About 5 days|
2. What is Trilostane?
Trilostane is an enzyme inhibiting medication. Its principal use is in the treatment of canine Cushing's disease. In some cases, trilostane may also be an appropriate treatment for horses, cats and other conditions.
It was withdrawn from human use in the United States market in April 1994. The drug was previously available in the United Kingdom for use in humans under the brand name Modrenal for the treatment of Cushing's disease and for breast cancer. It was approved in the United States in 2008 for the treatment of Cushing's disease (hyperadrenocorticism) in dogs under the brand name Vetoryl. It was available by prescription in the UK under the Vetoryl brand name for some time before it was approved in the US. The drug is also used to treat the skin disorder Alopecia X in dogs.It is also the first drug approved to treat both pituitary- and adrenal-dependent Cushing's in dogs. This prescription drug works by stopping the production of cortisol in the adrenal glands.
3. Mechanism of action/Effect:
Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.
4. Veterinary Medicine:Dogs and Cushing's Disease
Cushing's disease is most common in smaller dogs. Signs of Cushing's syndrome may include increased appetite, thirst and urination, hair loss, bald patches and an enlarged abdomen. Without treatment, dogs can develop weak and calcified skin patches, hepatopathy and frail abdominal muscles.
Canine Cushing's disease is caused by excess secretion of the adrenocorticotropic hormone, which elevates cortisol levels. Most dogs that develop Cushing's disease have pituitary dependant hyperadrenocorticism (PDH). Those who do not have Cushing's because of PDH have an adrenocortical tumor, which may be benign or malignant. Whether the result of an adrenal or pituitary tumor, Cushing's disease interferes with biological mechanisms that normally function to regulate cortisol blood levels.
5. Trilostane: Other Uses in Veterinary Medicine
In addition to treatment for pituitary dependant hyperadrenocorticism, adrenocortical tumors and Cushing's disease, Trilostane may be used to treat dogs with Alopecia X. Advancements in veterinary medicine have also led to substantial groundwork in the use of trilostane for treating horses with Cushing's.
Additionally, while PDH in felines is rare, trilostane may be a chosen form of therapy. However, trilostane has revealed to be a less successful form of treatment for cats.
6. Trilostane Side Effects:
Trilostane is well tolerated in most dogs. Transient biochemical abnormalities include mild hyperkalemia, azotemia, hyperbilirubinemia and hypercalemia.
There may be a subset of dogs in which trilostane blocks the synthesis of mineralocorticoids more effectively than gluccocorticoids. This group of dogs is at increased risk for adverse reactions including dehydration, weakness, hyponatremia and hypokalemia.
Side effects include lethargy, weakness, vomiting, anorexia and diarrhea. Rare fatalities have been reported. The incidence of side effects is higher with once a day dosing.
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