Payment & Shipping Terms:
|Product Name:||AICAR||Advantages:||Reship Policy|
|Type:||Pharmaceutical Intermediate||Appearance:||White Powder|
Pharma Raw Materials,
|Product Categories:||ARASINE;Cardiovascular APIs;PI3K/Akt/mTOR;PI3K;Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides;Protein Kinase;Akt;mTOR|
AICAR’s principal mechanism of action is activation of AMPK (AMP-activated protein kinase.) Activating AMPK, therefore, causes the same cellular machinery (so to speak) to be turned on as if the cell were energy deprived, for example from intensive exercise, or from low caloric intake.
AICAR, at sufficient and quite substantial concentration, is effective at activating AMPK and inducing a cellular state as if exercise had been performed, or energy stores were low and fat therefore needed to be burned.
AICAR uses metabolic pathways to block certain enzymes, which allows for AMP-activated protein kinase. This can be explained to the layperson like this: once you take a substantial amount of AICAR, it tricks your body at a cellular level in to thinking that exercise has just been preformed. Since the body thinks it has just done a considerable amount of exercise, the energy cycle at the cellular level starts converting fuel sources, like fatty acids, to output the energy that was thought to have been spent during exercise. This can have a direct effect on the level of endurance activity and the sustainability of that activity. Insulin sensitivity is also noted to be one action that AICAR produces, as the body will think it just went through a series of exercises. Interestingly, in animal studies with obese mice, AICAR showed all of the peptides benefits for obese diet induced mice, yet the healthy lean mice did not reap any of the benefits of insulin sensitivity or increase in glucose uptake. That being said, the application in bodybuilding does not seem very suitable, as these mechanisms are targeted for the out-of-shape and over-weight.
AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.
First, it’s an important pharmacological research agent, used principally as an AMPK activator. It’s a compound which has shown extremely impressive fat-loss and endurance-enhancing effects in laboratory animals. Further, it has considerable mystique resulting from at least some use by elite European cyclists. And lastly, it’s readily available from research chemical sites and is being personally tried by many, though generally as part of stacks and combined with changes in training and/or diet.
|Appearance||An odorless, almost white or white powder||pass|
The retention time of the major peak is
confirm to the RS
|Loss on Drying||Not more than 0.5%||0.33%|
|Assay(HPLC)||Not less than 99.0%||99.59%|
|Ignition residue||Not more than 0.1%||pass|
|Heavy metal||Not more than 20 ppm||pass|
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